Thymosin Alpha-1 you need to know

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Introduction

Formula: C129H215N33O55
Structure: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-GluGlu-Ala-Glu-Asn-OH

Thymosin Alpha 1 (Tα1), is a polypeptide hormone produced by thymic epithelial cells, that can effectively increase T-cell numbers and support T-cell maturation. T-cells are a part of the immune system that focus on distinct foreign particles and responsible for immunity to foreign substances.

Thymosin is a hormone secreted from the thymus gland, an organ that plays an important function both in the immune system and endocrine system. Thymosin also aids in the growth of B cells to plasma cells to develop antibodies.

Usage

Thymosin Alpha-1 activates various cells of the immune system and may have benefits in disorders where immune responses are ineffective or impaired and may need support. Some conditions that interest the use of Tα1 are chronic and acute bacterial and viral infections, vaccine non-responsiveness, Hepatitis B and C, Cystic fibrosis, DiGeorge’s syndrome, some cancers and chemotherapy adjunct, chronic inflammatory conditions, HIV/AIDS and other conditions that requirer immune response modulation.

Research study results suggest that treatment with Thymosin Alpha-1 can noticeably decrease mortality and reduce acute lung injury in critical type COVID-19 patients.

Mechanism of Action

Thymosin Alpha-1 discourages viral replication, restores stem cells, and supports the production of new immune cells. Once Tα1 assists to activate the immune system, it then aids to kill bacteria, fungal, viral infections and tumor cells.

Certain T-cells are responsible for finding and destroying our body’s own cells that are cancerous or infected with bacteria or viruses. Helper cells work with other cells of the immune system to achieve appropriate immune responses.Thymosin Alpha-1 has a pleiotropic mechanism of action, affecting several immune cell groups that are involved in immune suppression. Tα1 acts through Toll-like receptors (a class of proteins that play a key role in the innate immune system) in both myeloid and plasmacytoid dendritic cells, commanding the stimulation and activation of signaling pathways and production of immune-related cytokines.

Administration

Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area.

Before administering Thymosin Alpha-1 always be sure to use a clean and sterile syringe.

  1. Hold the Thymosin Alpha-1 vial upright and insert the syringe in the center of the cap.
  2. Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
  3. Before administering the syringe, use alcohol to cleanse the area of skin.
  4. Pinch the skin around the area to be injected, leave about 2 cm on each side.
  5. Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
  6. Depress the plunger fully, until the syringe is empty, and carefully draw out.

Dosage

Dosage Amount:

        Patients weighing > approximately 88 lb :250mcg (1mg) – 2 (2mg)

       Patients weighing < approximately 88 lb : 40mcg

Dosage Frequency:Twice weekly for 6-12 months

Side Effects

Although Thymosin Alpha-1 is typically well tolerated with no side effects when used in the recommended dosage, there are few that rarely occur, including redness and discomfort at the injection site, muscle atrophy, multiple joint aches and pains, and swelling and rash of the hand.

Benefits

  • Enhancement of the function of certain T-cells and dendritic cells
  • Eradication of compromised cells to stop multiplication of the unhealthy cells
  • Prevention of infections, viruses, and diseases from spreading further in the body
  • Exhibits antibacterial and anti-fungal properties
  • Suppression of tumor growth
  • Increase of vaccine effectiveness
  • Protection against oxidative damage
  • Improvement of the immune system so illness is avoided

Disclaimer

The content of this site is provided for information purposes only. It is not meant as a substitute for the advice of a medical professional. None of the content on this site should be relied upon to diagnose, treat, cure, or prevent any disease or medical condition.

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Thymosin Alpha-1 you need to know

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