Description
Usage: All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.
Data
Name: Tirzepatide
CAS No.: 2023788-19-2
PubChem CID: 156588324
IUPHAR/BPS: 11429
DrugBank: DB15171
ChemSpider: 76714503
UNII: OYN3CCI6QE
KEGG: D11360
ChEMBL: ChEMBL4297839
Formula: C225H348N48O68
Molar mass: 4813.527 g·mol−1
Other Names: LY3298176, GIP/GLP-1 RA
Purity: 98.5%min
Brand Name: UNEWLIFE
Grade: Pharm Medicine Grade
MFG: each batch fresh in 2023
Shelf Life: 2 years of proper storage
Appearance: White Powder
Test Reports: MS/COA/HPLC
Packing: 5mg*10vials/box
Label: without labels, can be OEM/ODM customized.
Box: white carton box, that can be OEM/ODM customized.
Shipping: by express or post.
Feedback: How do they say? More reviews here
For more questions, check the answers here: FAQ
Description
Tirzepatide is a first-in-class medication that activates both the GLP-1 and GIP receptors, which leads to improved blood sugar control.
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are hormones involved in blood sugar control.
Tirzepatide is indicated to improve blood sugar control in adults with type 2 diabetes, as an addition to diet and exercise.
Mechanism of action
Tirzepatide is an analogue of gastric inhibitory polypeptide (GIP), a human hormone that stimulates the release of insulin from the pancreas. Tirzepatide is a linear polypeptide of 39 amino acids that has been chemically modified by lipidation to improve its uptake into cells and its stability to metabolism. It completed phase III trials globally in 2021.
Tirzepatide has a greater affinity to GIP receptors than to GLP-1 receptors, and this dual agonist behavior has been shown to produce greater reductions of hyperglycemia compared to a selective GLP-1 receptor agonist. Signaling studies have shown that this is due to tirzepatide mimicking the actions of natural GIP at the GIP receptor. However, at the GLP-1 receptor, tirzepatide shows bias towards cAMP (a messenger associated with regulation of glycogen, sugar and lipid metabolism) generation, rather than β-arrestin recruitment. This combination of preference towards GIP receptor and distinct signaling properties at GLP-1 suggest this biased agonism increases insulin secretion.
Tirzepatide has also been shown to increase levels of adiponectin, an adipokine involved in the regulation of both glucose and lipid metabolism, with a maximum increase of 26% from baseline after 26 weeks, at the 10 mg dosage.
Jude (verified owner) –
I have tried semaglutide from you, amazing! Hope tirzepatide not let me down:)
Jaime (verified owner) –
I didnt have any experience with this, my friend Joe shared this to me, wow, great till now.
MusPro Gym (verified owner) –
I dont want someone else more to know your products actually, your are my secret garden shop, UNEWLIFE.
Landiy (verified owner) –
UNEWLIFE helped me save a lot of money I have to say. wonderful guys!
Claude3 (verified owner) –
Tirzepatide exceeded all my expectations. I feel and look like a new person. Shipping was fast, quality outstanding and support staff world class. Tirzepatide has truly been life changing and I would recommend it without hesitation.
Kristie (verified owner) –
I cannot say enough about how much tirzepatide has helped me. I lost over 70 pounds in 8 months, dropped 9 sizes and brought my A1C to a normal range for the first time in 15 years. Shipping and quality were stellar but support staff were the real stars. They guided and encouraged me throughout my journey. Tirzepatide is truly transformational and I would recommend it to anyone!