Semaglutide: 25mg (2.5mg*10vials/box)

(21 customer reviews)

Semaglutide: 2.5mg*10vials/box, 25mg/box

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Description

Usage: All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.

 

Read more: The Complete Semaglutide (GLP-1) Guidebook

 

Data

Name: Semaglutide

CAS No.: 910463-68-2

Other Names: Semaglutide/ NN9535/ 910463-68-2/ NN 9535

Molecular Formula: C187H291N45O59

Sequence: HXEGTFTSDV SSYLEGQAAK EFIAWLVRGR G

Molecular Weight: 4113.64 g/mol

PubChem CID: 56843331

Synonyms: GLP-1, proglucagon (72-108), glucagon-like peptide-1, Semaglutide

Purity: 98.5%min

Brand Name: UNEWLIFE

Grade: Pharm Medicine Grade

MFG: Fresh batch in 2023

Shelf Life: 2 years of proper storage

Appearance: White Powder

Test Reports: MS/COA/HPLC

Packing: upgraded to 2.5mg/vial,10 vials/Box total 25mg/box

Label: without labels, can be OEM/ODM customized.

Box: white carton box, that can be OEM/ODM customized.

Shipping: by express or post.

Feedback: How do they say? More reviews here

For more questions, check the answers here: FAQ 

 

 

Semaglutide

Description

Semaglutide is a recombinant DNA produced polypeptide analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents. There have been no published reports of hepatotoxicity attributed to semaglutide therapy.

Semaglutide is a polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes. It has a role as a hypoglycemic agent, a glucagon-like peptide-1 receptor agonist, an anti-obesity agent, a neuroprotective agent and an appetite depressant. It is a polypeptide and a lipopeptide.

 

 

Semaglutide (Glucagon-Like Peptide-1) Overview

Semaglutide, GLP-1, short for glucagon-like peptide-1 is a short, naturally occurring peptide hormone just 30-31 amino acids in length. Its primary physiologic function is to lower blood sugar levels by naturally enhancing insulin secretion. It also plays roles in protection beta cell insulin stores by promoting insulin gene transcription and has been linked with neurotrophic effects in the brain and central nervous system.
In the GI system, GLP-1 has been shown to significantly decrease appetite by delaying gastric emptying and reducing intestinal motility. Preliminary research has shown impacts of GLP-1 in the heart, fat, muscles, bones, liver, lungs, and kidneys as well.

The primary focus of GLP-1 research has been in the realm of diabetes treatment/prevention as well as appetite suppression. Secondary research focuses on the potential cardiovascular benefits of the peptide. More recent, and thus less robust, research focuses on the ability of GLP-1 to stave off neurodegenerative disease. Though this latter area of research is newest, it is also the fast-growing area of GLP-1 study now that the peptide has been revealed to slow or prevent the accumulation of amyloid beta plaques in the setting of Alzheimer’s disease.

Semaglutide is a glucagon-like peptide-1 receptor agonist. It increases the production of insulin, a hormone that lowers the blood sugar level. It also appears to enhance growth of β cells in the pancreas, which are the sites of insulin production.

In short, it inhibits glucagon, which is a hormone that increases blood sugar. It additionally reduces food intake by lowering appetite and slows down digestion in the stomach. In this way it reduces body fat.

 

Semaglutide GLP-1 research

The Incretin Effect of GLP-1

Perhaps the most important effect that GLP-1 has, according to Dr. Holst, is referred to as the “incretin effect.” Incretins are a group of metabolic hormones, released by the GI tract, that cause a decrease in blood glucose (sugar) levels. GLP-1 has been shown to be one of the two most important hormones (the other being GIP) to stimulate the incretin effect in rodent models. Though GIP circulates at levels roughly 10 times higher than that of GLP-1, there is evidence that GLP-1 is the more potent of the two molecules, particularly when levels of blood glucose are quite high.

A GLP-1 receptor has been identified on the surface of pancreatic beta cells, making it clear that GLP-1 directly stimulates the exocytosis of insulin from the pancreas. When combined with sulfonylurea drugs, GLP-1 has been shown to boost insulin secretion enough to cause mild hypoglycemia in up to 40% of subjects[1]. Of course, increased insulin secretion is associated with a number of trophic effects including increased protein synthesis, reduction in the breakdown of protein, and increased uptake of amino acids by skeletal muscle.

 

GLP-1 and Beta Cell Protection

Research in animal models suggests that GLP-1 can stimulate the growth and proliferation of pancreatic beta cells and that it may stimulate the differentiation of new beta cells form progenitors in the pancreatic duct epithelium. Research has also shown that GLP-1 inhibits beta cell apoptosis. Taken in sum, these effects tip the usual balance of beta cell growth and death toward growth, suggesting that the peptide may be useful in treating diabetes and in protecting the pancreas against insult that harms beta cells.

In one particularly compelling trial, GLP-1 was shown to inhibit the death of beta cells caused by enhanced levels of inflammatory cytokines. In fact, mouse models of type 1 diabetes have revealed that GLP-1 protects islet cells from destruction and may, in fact, be a useful means of preventing onset of the type 1 diabetes.

 

GLP-1 and Appetite

Research in mouse models suggests that administration of GLP-1, and its similar cousin GLP-1, into the brains of mice can reduce the drive to eat and inhibit food intake. It appears that GLP-1 may actually enhance feelings of satiety, helping individuals to feel fuller and reducing hunger indirectly. Recent clinical studies have shown in mice that twice daily administration of GLP-1 receptor agonists cause gradual, linear weight loss. Over a long period, this weight loss is associated with significant improvement in cardiovascular risk factors and a reduction in hemoglobin A1C levels, the latter of these being a proxy marker for the severity of diabetes and the quality of blood sugar control attained via treatment.

 

Potential Cardiovascular Benefits of GLP-1

It is now know that GLP-1 receptors are distributed throughout the heart and act to improve cardiac function in certain settings by boosting heart rate and reducing left ventricular end-diastolic pressure. The latter may not seem like much, but increased LV end-diastolic pressure is associated with LV hypertrophy, cardiac remodeling, and eventual heart failure.

Recent evidence has even suggested that GLP-1 could play role in decreasing the overall damaged caused by a heart attack. It appears that the peptide improves cardiac muscle glucose uptake, thereby helping struggling ischemic heart muscle cells to get the nutrition they need to continue functioning and avoid programmed cell death. The increase in glucose uptake in these cells appears to independent of insulin.

Large infusions of GLP-1 into dogs have been shown to improve LV performance and reduce systemic vascular resistance. The latter effect can help to reduce blood pressure and ease strain on the heart as a result. This, in turn, can help to reduce the long-term consequences of high blood pressure such as LV remodeling, vascular thickening, and heart failure. According to Dr. Holst, administration of GLP-1 following cardiac injury has “constantly increased myocardial performance both in experimental animal models and in patients.”

 

GLP-1 and the Brain

There is some evidence to suggest that GLP-1 can improve learning and help to protect neurons against neurodegenerative diseases such as Alzheimer’s disease. In one study, GLP-1 was shown to enhance associative and spatial learning in mice and even to improve learning deficits in mice with specific gene defects. In rats that over-express the GLP-1 receptor in certain regions of the brain, learning and memory are both significantly better than in their normal controls.

Additional research in mice has shown that GLP-1 can help to protect against excitotoxic neuron damage, completely protecting rat models of neurodegeneration against glutamate-induced apoptosis. The peptide can even stimulate neurite outgrowth in cultured cells. Researchers are hopeful that additional research on GLP-1 will reveal how it might be used to halt or reverse certain neurodegenerative diseases.

Interestingly, GLP-1 and its analogue exendin-4 have been shown in mouse models to reduce levels of amyloid-beta in the brain as well as the beta-amyloid precursor protein found in neurons. Amyloid beta is the primary component of the plaques observed in Alzheimer’s disease, plaques which, while not necessarily known to be causative, are associated with the severity of the disease. It remains to be seen if preventing amyloid beta accumulation can protect against the effects of Alzheimer’s disease, but this research is, at the very least, a tantalizing clue as to how scientists my intervene in the progression of mild cognitive impairment to full Alzheimer’s disease.

GLP-1 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans.

 

 

 

 

 

Additional information

Weight 100 g
Dimensions 100 × 100 × 20 mm
Brand

UNEWLIFE

Specification

10vials/box

Packing

discreet packing safe delivery

Appearance

White lyophilized powder

Purity

>98.5%

Test method

HPLC/MS/COA

Labels/Box

Print on demand

Application

Pharmaceutical medicine Grade

21 reviews for Semaglutide: 25mg (2.5mg*10vials/box)

  1. Shiraz nisar (verified owner)

    amazing product!

  2. Lee (verified owner)

    Big Jill in FB group introduced this thanks a lot!!!

  3. Charles (verified owner)

    shiping takes a little more days than i had expacted but working great, guys thank you.

  4. Smirnov (verified owner)

    i searched semaglutide and found your this blog post: Semaglutide VS Orlistat, Safe weight loss solution?
    then I was flicking through most of your articles and they are quite professionally, so I think you guys working should be serious. I ordered semaglutide and hgh, and they have not disappointed me, very good products, and UNEWLIFE is a responsible and enthusiastic team, thank you!

  5. Jennifer (verified owner)

    YOUR price too good to be true! the best place to buy semaglutide here.Nice packed!

  6. Avalita (verified owner)

    The price for this seems really suspicious, but I just received my order yesterday and all is good. The packaging was very discreet and tidy, too. So far, so good, and I will be a repeat customer. Thanks, guys!

  7. Abo (verified owner)

    my friend told me this on Reddit and I tried them new way of WL, which has substantial positive changes these days.

  8. Patricia Robinson (verified owner)

    I have ordered 3rd times. My last order tracking hasn’t been updated for 1month. Generally, it should be delivered within 2 weeks. I consulted their support team, and they sent me another set for free, on the way now, I can’t wait, the last one is almost used up.

  9. Leo (verified owner)

    Me encantó, subí unos kilos desde la 2da semana, y me ayudó a bajar rápido lo cual tuve que parar, me funcionó muy bien. Lo recomiendo fuertemente.

  10. Joshua (verified owner)

    Works as described…after a few weeks of taking

  11. Andrea (verified owner)

    It works well for what it is. Solid product

  12. Murphy (verified owner)

    Longer days than I had expected but it works well, good one, worth to try again.

  13. Dr.Edwards (verified owner)

    This stuff really works!

  14. Anna (verified owner)

    I’ve been taking it for a few months now and have noticed a significant improvement in weight management. It’s easy to use and has made a real difference in my life.

  15. Amanda (verified owner)

    Semaglutide has been a game changer for me! It’s helped me control my blood sugar levels and lose weight. Highly recommend it!

  16. Maricus (verified owner)

    Its just what I ordered

  17. Lucy (verified owner)

    Great customer service and effective product. Happy with my purchase.

  18. 11 Healthcare (verified owner)

    The product arrived earlier than expected, and the packaging was secure. The customer service team was helpful and provided me with all the necessary information. The product itself is of exceptional quality and has noticeably improved my overall well-being.

  19. Susan (verified owner)

    Initially, I encountered some challenges with payment as the only accepted method was Bitcoin. However, after taking the time to learn and navigate the process, I successfully completed the transaction. Throughout the order processing, I felt a sense of worry, but my concerns were alleviated when the parcel arrived at my doorstep. Upon opening and testing the product, I was pleased to find that it exceeded my expectations. Overall, despite the payment inconvenience, the product’s performance made it worth the extra effort.

  20. B&B (verified owner)

    Clear communication, quick response, and top-notch quality. Impressed!

  21. Weliton (verified owner)

    They offer these semaglutide with affordable price and exceptional results . Couldn’t be happier:D

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