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Epithalon 10mg*10vials/box

(2 customer reviews)

Epithalon 10mg*10vials/box

Description

Usage: All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.

 
Name: Epithalon

CAS No.: 307297-39-8

Other Names: Epitalon

Purity: 98.5%min

Brand Name: unewlife

Grade: Pharm medicine Grade

MFG: each batch fresh in 2022

Shelf Life: 2 years proper storage

Appearance: White Powder

Test Reports: MS/COA/HPLC

Packing: 10mg/vial,10 vials/Box

Label: without labels, can be OEM/ODM customized.

Box: caton white box, can be OEM/ODM customized.

Shipping: by express or post.

Feedbacks: How they say? More reviews here

More questions, check the answers here: FAQ 

Description

Epithalon is a peptide used to regulate the cell cycle through up-regulation of telomerase activity.

The sequence of amino acids in the peptide is Alanine-Glutamate-Asparagine-Glycine.

Animal studies have been done on the effects of Epithalon on suppression of spontaneous mammary tumors and spontaneous carcinogenesis. Studies have shown that the mode of action of Epithalon involves suppression of oncogene expression and modification of telomerase activity.

A summary of the studies and research on telomerase is provided below.

Telomerase is a specific RNA (ribonucleic acid)-dependent polymerase that elongates and maintains the length of telomeres by adding tandem repeats on the chromosomal 3′ end. The enzyme is composed of two parts: an RNA component which supplies the telomere template for elongation, and the catalytic subunit which possesses reverse transcriptase activity.

These two parts work in tandem to avert telomere attrition especially in somatic cells. In vitro experiments have shown that telomere elongation promotes indefinite cellular proliferation and that suppression of telomerase activity promotes apoptosis of neoplastic cells.

However, these studies have also shown that maintenance of telomere length within a range of 15-20 kilobase pairs does prevent tumorigenesis. All the research and studies done concerning telomerase do show that telomerase activity is limited to cell division through its action of stabilizing the telomere length.

Telomeres are located at either ends of a chromosome, and they do protect the adjacent gene sequence from shortening due to repeated replication cycles. Elongation of telomeres enables senescent cells to stabilize their telomeric length. However, excess elongation would enable such cells to exceed their Hayflick limit via evasion of apoptosis or the post-mitotic phase; and therefore, such cells have the potential of becoming immortal and this predisposes them to neoplastic transformation. Human telomeres are made up of tandem repeats of the nucleotide sequence TTAGGG that form a T loop structure when associated with telomere-binding proteins.

The T loop structure ensures the integrity of the telomeres by protecting them from constitutive degradation. These tandem repeats do shorten as a consequence of repeated chromosomal replication cycles. Such shortening is due to the inability of DNA polymerase to repeatedly replicate the nucleotides located in the T loop region.

This leads to senescence or growth arrest, and a critically shortened telomere does induce a p53-mediated DNA checkpoint reaction.

Some cells do evade senescence if they have nonfunctional p53 and/or pRb, but cell death still occurs due to either lethal DNA rearrangements or chromosomal fusion. Thus, evasion of telomere-mediated senescence is the main way that cells use to avert premature senescence and apoptosis.

This occurs only when telomerase activity is up-regulated. Telomerase elongation leads to stabilization of the genotype as the rate of gene mutation is maintained within normal limits. However, an increase in the rate of apoptosis leads to a proportionate increase in cellular regeneration rate, and this causes an increase in the number of sporadic gene mutations that occur thus predisposing the person to pro-neoplastic mutations.

Current studies show that telomere shortening is associated with chronic diseases such as pulmonary fibrosis, coronary artery disease, diabetes mellitus and Alzheimer’s disease, though their findings are still considered inconclusive. Based on the findings of these studies, it can be theorized that Epithalon could prevent the development of these diseases.

Additional information

Weight 100 g
Dimensions 100 × 100 × 20 mm
Brand

UNEWLIFE

Specification

10vials/box

Packing

discreet packing safe delivery

Appearance

White lyophilized powder

Purity

>98.5%

Test method

HPLC/MS/COA

Labels/Box

Print on demand

Application

Pharmaceutical medicine Grade

2 reviews for Epithalon 10mg*10vials/box

  1. Ilanah (verified owner)

    Would definetly order from them again, can’t wait to see how the rest of their products are!!

  2. Matt (verified owner)

    MY OVERALL EXPERIENCE
    My overall experience with this source has been excellent. will order from again.

    PRODUCTS, EFFECTIVENESS AND RESULTS
    Items ordered hgh and epithalon. excellent all day long.

    CUSTOMER SERVICE
    The customer service was so good every step shop will note by mail and received my package discreetly, no signature.

    SHIPPING AND DELIVERY
    Delivery about 10days after trace number sent to me and discreet packed well and safely, I am very satisfied with this service

    PRICE
    Amazing, amzing and amazing. 10/10 would recommend!

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