HGH and Peptide Therapy

“If you’re a man over 30, you need to read this book!”

Dr. Melissa Loseke

Table of Contents

As you’ve gotten older, you may have noticed that you’ve put on a few pounds. Your joints are probably a little achier than they used to be, and your sexual desire might be virtually non-existent.
While these may be something you simply attribute to aging, it can be more than that. The peptides that were once responsible for signaling the secretion of crucial hormones likely have decreased over the years.
For instance, as you age, your human growth hormone (HGH) levels begin to decline. HGH is partially responsible for destroying fat cells, increasing lean muscle mass, and reducing swelling and inflammation. But with Peptide Therapy, you can safely restore these levels to help your body function at an optimal level.

What Are Peptides?

Peptides are short-chain amino acids found naturally in the body. Amino acids are the building blocks of protein and these particular amino acids are designed to augment specific functions within the human body.
Peptide Therapy uses sequences already present to regulate and rejuvenate functions. They are a signaling agent. They bind to and tell other cells what to do, replacing or mimicking the functions of naturally occurring peptides.

Peptides can rewrite body chemistry relationships to promote restoration, anabolism, and homeostasis.
There are over 7,000 different types of peptides. Peptides have dozens of uses but the most common uses are helping to help with sleep, build muscle and reduce fat, improve energy, improve sexual function, and reduce GI and musculoskeletal inflammation.
Some of the commonly prescribed peptide combinations function to naturally boost growth hormone for better recovery.
Some of the many benefits of different peptides include:
• Increased development of lean muscle growth
• Faster recovery time from workouts
• Reduced body fat
• Increased energy and stamina
• Increased muscle mass and endurance
• Accelerated healing from wounds or surgery
• Stronger immune system
• Improved regulation of other hormones
• Stronger libido
• Increased natural HGH production

Why is HGH Production Important?

What’s the deal with HGH? Why is it important and why should I care about it? Great questions.
Human Growth Hormone (HGH or GH for short) plays several important roles including the maintenance of lean body mass, promoting fat-burning, improving the cardiovascular system, as well as cognitive benefits.
From aerobic endurance to building lean muscle, GH is involved in quite a bit. And while Growth Hormone gets its name from its important role in childhood development, it’s purpose extends far into adulthood. Even throughout adult life, it remains one of the most
abundant hormones in the pituitary gland.
But as we continue to age, GH production declines, which starts to produce unwelcome side effects.

Low levels of GH have been associated with reductions in muscle mass and strength as well as an increase in body fat, especially belly fat.
Additionally, there have been side effects of aging that have also been associated with a decrease in nighttime growth hormone secretion. These include a decrease in memory and cognitive function and sleep disorders. GH hormone pulse peaks/is at its highest
during sleep. Not getting good sleep also affects production.
And while these declines only show an association between aging and low GH levels, it led to the assumed conclusion that replacing or stimulating GH could reverse some of the aging-related symptoms.

What is HGH?

HGH is important throughout life. But what exactly is it?

Human growth hormone is a peptide secreted by the pituitary gland. It acts
through binding to the HGH receptor, inducing either direct effects or initiating the production of insulin-like growth factor I (IGF-I), the most important mediator of HGH effects.
But GH is more than just an “anti-aging” formula. Several dangers are associated with GH deficiencies. Body composition is often significantly different marked by an increase in fat, predominantly in the stomach, and a decrease in muscle mass, which leads to reduced muscle strength and exercise capacity.
Weight is harder to control, and the general well-being of GH deficient adults may be affected, leading to reduced vitality and energy.

Read more: Growth Hormone you need to know

What Causes HGH Deficiency?

While aging is the primary cause, a variety of other factors can cause a decline including poor/lack of sleep, obesity, exercise, stress, and body composition. Furthermore, Adult growth hormone deficiency (AGHD) is becoming more common and has been thought to be associated with premature mortality.
Starting in your 30s, there is a slow decline of GH secretion.

You lose about 15% every decade. GH secretion typically peaks in puberty at about 150 μg/kg day, then decreases to approximately 25 μg/kg/day by age 55.

Additionally, damage to the pituitary gland, whether as an adult or child, can further decrease GH secretions. As GH secretions continue to drop, the psychological well-being may also be impaired, and this comes in the form of depressed moods and increased anxiety levels.
Bone mass is reduced and combined with an increase in body fat, can lead to sarcopenic obesity and frailty. The decline in GH may also play a role in cognitive changes observed with aging. One of the many systems for classifying different cognitive domains is grouping them as either “crystallized” or “fluid” intelligence.

Crystallized intelligence generally refers to vocabulary and long-term memory; whereas fluid intelligence includes short term memory and active problem-solving and demonstrates a more marked age-related decline. Several studies have shown a correlation between plasma IGF-I concentrations and performance on tests of fluid intelligence, suggesting that GH may play a role in the maintenance of fluid intelligence.

What to Look For?

Symptoms can come in a variety of forms including cognitive, cardiac, muscular, metabolic, and bone symptoms. Some of the more prominent symptoms include:
• Anxiety and depression
• A Decrease in muscle mass and strength
• A Decrease in sexual function/interest
• Fatigue/low energy
• Elevated triglyceride levels
• Difficulty concentrating or lack of memory
• Increased abdominal fat
• Reduced vitality and energy
And those are just some of the most frequently seen symptoms. Changes in memory, processing speed, and attention are greatly reduced. Psychological effects such as social isolation, low self-esteem, poor self-control, and poor marital and socio-economic
performance are also possible.

If you’re experiencing any of these symptoms, a simple blood test and consultation with a trained provider can help determine if you’re suffering from an HGH deficiency.

Would Peptide Therapy Benefit Me?

In short, most would benefit from peptide therapy.

Our day-to-day lives can cause a lot of pain. Peptides can improve our lifestyles to help remove knee pain, back pain, shoulder pain, and more.

Peptides are a very safe option and we’ve had no reported adverse side effects with any of the peptides that we have used with our patients.
Peptide therapy is no miracle solution to your aches and pains, but it does help significantly with quite a few of them. It can also be used in combination with other treatments such as Testosterone Replacement Therapy to enhance and increase your results. It’s a great way to improve your health without resorting to multiple treatment options or enduring expensive procedures.

Peptides can treat very specific conditions in the body, leading to a wide range of benefits. They can be used to improve your overall health and wellness as well as provide anti-aging benefits. Some of the conditions it can improve are inflammation, weight management, low libido, growth hormone deficiency, anxiety and depression, joint pain, lack of mental clarity and focus, insomnia, and more.

Some of the most commonly used peptides include Ipamorelin, Sermorelin, PT-141, and BPC-157.


Benefits of Ipamorelin include:
• Decreased body fat
• Increased collagen production
• Increased lean muscle mass
• Improved sleep
• Increased cellular repair and Regeneration
• Increased IGF-1
• Increases bone mineral content
• Counteracts glucocorticoid catabolic effects
• Less appetite stimulation than GHRP-6
• Less release of cortisol, prolactin, and aldosterone

Ipamorelin is used to help augment growth hormone production. It’s not a synthetic growth hormone, rather a medication that’s designed after the hormone that exists in our body to help the pituitary gland produce more growth hormone naturally.
Composed of 5 amino acids, Ipamorelin is a growth hormone secretagogue that stimulates the pituitary gland to release more growth hormone.

Ipamorelin helps your body burn fat and recover from workouts sooner. And if you add exercise to your routine, you’ll lose weight at a faster rate. Ipamorelin also includes anti-aging properties, helps improve your sleep cycle, and can enhance your immune system.

Ipamorelin is one of the latest and greatest peptides in the growth factor family. Deemed one of the safest GHRP’s, Ipamorelin is a selective growth hormone (GH) Secretagogue and Ghrelin receptor agonist.
This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class.

Human Growth Hormone (HGH) peaks at about age 20 and steadily declines as we age. When used alone or in conjunction with other peptides, Ipamorelin can boost your HGH levels helping to slow the process of aging so that you can live your best life.

Ipamorelin is not only much less expensive than synthetic HGH but much safer as well. Ipamorelin and similar peptides stimulate the production and release of HGH from your pituitary gland instead of directly injecting your body with HGH. It also acts differently than
other HGH peptides, Ipamorelin mimics ghrelin (in the same way that Sermorelin mimics GHRH, more on Sermorelin next). Ghrelin plays a huge role in metabolism by increasing or decreasing hunger, initiating stored fat breakdown for the body to use as energy, and prevents the breakdown of muscles.
While Ipamorelin and synthetic HGH have similar benefits, only synthetic HGH carries potentially dangerous side effects such as the shutdown of natural HGH production, risk of excessive dosage, carpal tunnel syndrome, abnormal bone and tissue growth, and an enlarged heart.

Read more: Ipamorelin you need to know


Another powerful growth hormone-releasing peptide is Sermorelin.
Just like Ipamorelin, Sermorelin is a growth hormone peptide, but it works differently in the body (stimulates GHRH instead of ghrelin) to accomplish the same thing – stimulating growth hormone release from the pituitary gland. Read more: Sermorelin you need to know

Benefits of Sermorelin include:
• Increased lean body mass
• Body fat reduction
• Improved energy and vitality
• Increased endurance and strength
• Accelerated wound healing
• Improved immune function
• Improved cardiovascular function
• Improved sexual performance and libido
• Improved sleep

Overall, both Ipamorelin and Sermorelin support natural HGH production which is essential for overall cell regeneration and cell reproduction, leading to improved vitality, cognitive function, and overall anti-aging benefits.

When Can I Expect to See Results?

While patients will notice some significant changes in the body after the first month, the full benefits are usually fully noticed after four to six months of therapy.

Month 1
• Ease of mind, contentedness, better attitude
• Increased energy
• Improved stamina
• Deeper, more restful sleep
• Weight loss/decreased body fat

Month 2
• Improved skin, reduced wrinkles
• Stronger nails and hair
• Increased muscle tone
• Increased metabolism
• Reduction in belly fat

Month 3
• Noticeable feelings of ambition
• Enhanced sex drive and performance
• Improved mental focus
• Better flexibility
• Improved joint health

Month 4
• Continued weight reduction
• Improved skin elasticity
• Increased lean muscle mass

Month 5
• Noticeably fuller and healthier hair
• Reduced appearance of wrinkles, better skin tone
• Continued reduction in belly fat

Month 6
• 5-10% reduction in body fat (without exercise/diet)
• 10% increase in lean muscle mass
• Improved vitality due to organ regrowth
• Greatly improved physique


PT-141 is a new innovative peptide hormone treatment that works for both men and women to improve sexual function.

PT-141 is an effective and efficient treatment for both erectile dysfunction and increased libido in men and improves female sexual arousal disorder in women.
PT-141 works directly through the nervous system to increase arousal, desire, and satisfaction with sex.

Treatments like Viagra and Cialis work through the vascular system and only give you the ability to achieve an erection. However, PT-141 peptide gives you the desire and motivation along with the ability to achieve an erection, returning the intimacy and passion to your relationship.

Read more: PT-141 Bremelanotide you may need to know

And because PT-141 works through the nervous system and not the cardiovascular system, it can be a safer option for a wider variety of people, including those suffering from heart conditions, but still wish to maintain a healthy sex life.
Some of the key benefits of PT-141 include:
• Improved sexual desire and performance
• Regained self-esteem and confidence
• Improved relationship with your partner
• Return to healthy sexual intercourse
• Better, healthier sex which enhances mood, reduces stress and lessens depression
• Increased benefits when combined with other treatments and hormone therapies


Another powerful peptide is BPC-157.
BPC-157 is a molecule that is isolated in the gastric juice to help with gut health. It increases vascular flow to the tendons and ligaments to increase healing. Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this
peptide. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues. Read more: BPC-157 you need to know

Benefits of BPC 157 include:
• Accelerated wound healing (muscle, ligament, tendon, nerve)
• Anti-inflammatory
• Has been shown to decrease pain in damaged areas
• BPC 157 increases growth hormone receptors
• Promotes the outgrowth of tendon fibroblasts, cell survival under stress, and the migration of tendon fibroblasts
• Improves digestive function
• May improve blood pressure and NO production
• Protects and heals inflamed intestinal epithelium (leaky gut)
• It has also been shown to help with Inflammatory Bowel Syndrome
• Protects the liver from toxic insults (alcohol, antibiotics, etc) and promotes healing
Overall, BPC-157 is a great option to help alleviate joint pain, old injuries, and those looking to improve joint mobility.


Peptides are specific to function intended, have a very high safety factor, and are well-tolerated by patients. Because of these properties, peptides are the future of regenerative medicine and are dramatically changing the lives of those seeking longevity and well-being.

Peptides continue to grow in many treatment aspects including weight loss (muscle preservation), immune system issues, growth hormone, and overall skin care, anti-aging.
At UNewLife, we have several peptides that we offer for our patients, and we often prescribe a combination of peptides for optimal results. Peptides are appropriate for men and women alike, no matter your age.
If peptide therapy is something, you’d like to learn more about, you can check out our peptide therapy options at UNewLife.com

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HGH and Peptide Therapy