Bryan Johnson is quite a determined person. He was already a billionaire in Silicon Valley in his thirties, in 1977. However, at that time, his wife divorced him, and his body collapsed due to overwork. He even suffered from severe depression and contemplated suicide.
Later on, for reasons unknown, he suddenly realized that nothing was more important than his health. So he began to exercise vigorously to slow down aging. In 2021, he announced a plan called the Blueprint Plan. It involves taking experimental drugs, regular exercise, scientific sleep schedules, and other methods to reverse aging, not just to slow it down. For example, he wakes up at 5 a.m. every day, exercises for 67 minutes, consumes 1977 calories per day, goes to bed at 8:30 p.m. sharp, takes many relevant drugs, and so on.
It may sound a bit mysterious, but he really succeeded. Recently, Bryan’s medical team announced that his body had become 5.7 years younger. At 45 years old this year, his heart has returned to the level of a 37-year-old, his skin is at the level of a 28-year-old, and his lungs are at the level of an 18-year-old.
I’ve included a picture of Bryan in the text. He may not be as young as an 18-year-old boy, but he’s definitely a 45-year-old person in excellent shape.
However, it may be difficult for us to follow Bryan’s lead. Firstly, it takes too much time. Secondly, it’s too expensive. Bryan announced to the public that it costs $2 million per year to become young again, but in fact, he has allocated a budget of $800 million for this purpose. He planned to use all of the $800 million that he earned from selling his company to eBay for reversing his age.
But don’t be disappointed. Recently, I happened to see an article on SingularityHub that reprinted a new study from a sub-journal of “Nature” by a team from Columbia University. The title is how to become younger by changing the bone marrow hematopoietic environment?
To understand this study, we need to know why humans age. One of the most important reasons is that the function of hematopoietic stem cells declines.
Hematopoietic stem cells, or stem cells for short, are like the trunk of a tree, from which branches and fruits grow. They are the origin of all blood and immune cells and can differentiate into various tissue cells. Therefore, in medicine, hematopoietic stem cells are also called universal cells or progenitor cells. One of its most important abilities is to transform into various types of cells.
One of the reasons for the body’s aging is that the differentiation and transformation ability of hematopoietic stem cells declines. Studies have shown that as age increases, the differentiation of hematopoietic stem cells also changes. Originally, they could differentiate into various types of cells, but after aging, their differentiation begins to decline.
The research from Columbia University suggests that by changing the hematopoietic stem cell (HSC) microenvironment, we may be able to reverse aging. The microenvironment, or niche, is the environment surrounding the stem cells that play a crucial role in their function and maintenance.
The study found that by reducing a specific type of cell called leptin receptor-positive stromal cells (LepR+ cells) in the HSC niche, they were able to rejuvenate aged HSCs and improve their function. This resulted in improved immune function and increased lifespan in mice.
While the research is still in its early stages and more studies are needed to confirm the results, it provides hope that we may one day be able to reverse aging through more accessible and affordable means than the methods currently used by billionaires like Bryan Johnson.
In summary, while billionaires like Bryan Johnson are able to reverse aging through expensive and time-consuming methods, recent research suggests that it may be possible to achieve similar results by changing the microenvironment of stem cells. However, more research is needed to confirm these findings and develop more accessible and affordable methods for the general population.
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